Restylane is a line of hyaluronic acid–based facial fillers that help smooth wrinkles and plump your cheeks and lips1. Hyaluronic acid occurs naturally in our skin, especially in connective tissue1. It’s typically used in cheeks, lips, nasolabial folds, and around your mouth1. Restylane is one of the two types of dermal fillers used for the treatment of wrinkles, the other being Juvéderm2. Both injections use a gel made with hyaluronic acid to plump up the skin2. These are noninvasive procedures, and no surgery is required2.