Mofilet 500mg Tablets Mofilets-500 contains Mycophenolate Mofetil, a 2-morpholinoethyl ester prodrug of mycophenolic acid (MPA). MPA is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an essential rate-limiting enzyme in the de novo synthesis pathway of guanosine nucleotides. Because T- and B-lymphocytes rely predominantly on de novo purine synthesis for proliferation, MPA selectively inhibits lymphocyte growth, proliferation, and antibody response, reducing cell-mediated and humoral immune activity. Mofilets-500 is indicated for the prophylaxis of organ rejection in patients receiving allogeneic renal, hepatic, or cardiac transplants, administered in combination with cyclosporine and corticosteroids.