Rybelsus 14mg Tablets RYBELSUS contains Semaglutide, a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist that functions as an incretin mimetic. Semaglutide selectively binds to and activates the GLP-1 receptor, stimulating glucose-dependent insulin secretion from pancreatic beta cells while suppressing inappropriately elevated glucagon secretion from alpha cells. Additionally, it delays gastric emptying and promotes central satiety, leading to reduced overall caloric intake. Co-formulated with the absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC), oral semaglutide achieves systemic absorption via the gastric mucosa. RYBELSUS 14 mg is indicated as a maintenance dose adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.