Valgan 450 mg Tablets Valgan 450 mg contains Valganciclovir Hydrochloride, an L-valyl ester prodrug of ganciclovir. Upon oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is subsequently phosphorylated to ganciclovir triphosphate, which competitively inhibits viral DNA polymerases and incorporates into viral DNA, leading to the termination of viral DNA elongation. It is indicated for the treatment of Cytomegalovirus (CMV) retinitis in adult patients with acquired immunodeficiency syndrome (AIDS), and for the prevention of CMV disease in high-risk solid organ transplant recipients (such as kidney, heart, or kidney-pancreas transplant patients).