Esentra 120 Esentra 120 contains Denosumab 120 mg, a monoclonal antibody used to help protect bones in patients with certain types of cancer. It reduces excessive bone breakdown by blocking the activity of osteoclasts, helping lower the risk of fractures, spinal cord compression, and other bone-related complications. Esentra 120 is administered by a healthcare professional as part of an oncology treatment plan.