Imatib 100 Tablets Imatib 100 contains Imatinib, a selective protein-tyrosine kinase inhibitor that targets the BCR-ABL tyrosine kinase created by the Philadelphia chromosome abnormality. It also inhibits receptor tyrosine kinases for platelet-derived growth factor (PDGFR) and stem cell factor (SCF)/c-KIT. By blocking these pathways, it inhibits cellular proliferation and induces apoptosis in BCR-ABL positive cells and c-KIT positive tumor cells. It is indicated for the treatment of newly diagnosed Philadelphia chromosome-positive Chronic Myeloid Leukemia (Ph+ CML), Ph+ Acute Lymphoblastic Leukemia (ALL), Gastrointestinal Stromal Tumors (GIST), and Myelodysplastic/Myeloproliferative Diseases.